Abstract: Platelets are a limited and expensive blood product. Some patients do not respond appropriately to platelet transfusions due to antibodies targeting specific human leukocyte antigens (HLAs) expressed on platelets. Integrating complex donor and patient HLA testing results in real-time for clinical transfusion decision-making is time-consuming and potentially error prone. Using R and the Shiny framework, a web-based application (PLTVXM) was designed to help facilitate such tasks. Use of PLTVXM significantly improved task efficiency and accuracy for transfusion staff.

Describe the new knowledge and additional skills the participant will gain after attending your presentation.: Participants will learn about the clinical challenges surrounding platelet transfusions including the immune factors that can adversely affect clinical responses to these treatments. Participants will also learn about how R and Shiny can be used by subject matter experts, along with standards-based application programming interfaces, to rapidly prototype data-driven web-based applications and the impact such applications can potentially have on work flow and clinical care.

Authors:

Justin Juskewitch (Presenter)
Mayo Clinic

Manish Gandhi, Mayo Clinic
Justin Kreuter, Mayo Clinic
Andrew Norgan, Mayo Clinic